Publications

December 9-13 2014
San Antonio Breast Cancer Symposium

RAD1901, a Novel Tissue-Selective Estrogen Receptor Degrader (SERD) Demonstrates Estrogen Receptor Engagement in a Phase 1 Clinical Study

G Hattersley, F David, A Harris, M Clarkin, K Banks, G Williams, A Glaudemans, J Doorduin, M Koole, E de Vries, R Lyttle

 

 
November 13, 2014
Journal of Clinical Endocrinology and Metabolism

Effects of Abaloparatide, a Human Parathyroid Hormone-related Peptide Analog, on Bone Mineral Density in Postmenopausal Women with Osteoporosis

B Leder, L O'Dea, J Zanchetta, P Kumar, K Banks, K McKay, C Lyttle, G Hattersley

 

 
September 19-20 2014
4th Annual Brain Metastases Research and Emerging Therapy Conference

RAD1901, A Novel Tissue-Selective Estrogen Receptor Degrader (SERD) Optimized for Blood-Brain Barrier Penetration.

G Hattersley, F David, A Harris, M Clarkin, G Williams, R Lyttle

 

 
September 12-15 2014
American Society of Bone and Mineral Research

Responder Analysis of the Effects of Abaloparatide and Teriparatide on Bone Mineral Density in Postmenopausal Women With Osteoporosis

B Leder, K Banks, L O'Dea, C.R. Lyttle, J Yates, G Hattersley

 

 
September 12-15 2014
American Society of Bone and Mineral Research

The Long Term Effects Of Abaloparatide (BA058) On Micro-CT and Histomorphometry in Osteopenic Cynomolgus Monkeys

A Varela, S Haile, N Doyle, S Smith, R Guldberg, G Hattersley

 

 
September 12-15 2014
American Society of Bone and Mineral Research

Abaloparatide (BA058), a Human PTHrP Analog: Correlation of In vivo Bone Mass Gains and Improved Bone Strength in an Osteopenic Rat Model

A Varela, E Lesage, S Smith, G Hattersley

 

 
September 12-15 2014
American Society of Bone and Mineral Research

Abaloparatide (BA058), a Human PTHrP Analog: Correlation of In Vivo Bone Mass Gains and Improved Bone Strength in the Osteopenic Cynomolgus Monkey

N Doyle, A Varela, S Smith, G Hattersley

 

 
September 12-15 2014
American Society of Bone and Mineral Research

Comparing the Incidence of Bone Tumors in Rats Chronically Exposed to Abaloparatide (BA058) or PTH(1-34)

J Jolette, A Varela, B Attalla, S Smith, G Hattersley

 

 
September 12-15 2014
American Society of Bone and Mineral Research

The Long Term Effects Of Abaloparatide (BA058) On Bone Histomorphometry in Osteopenic Rats

L Chouinard, E Lesage, S Smith, G Hattersley

 

June 21-24 2014
The Endocrine Society Annual Meeting - Abstract

Differential Binding Selectivity of Abaloparatide (BA058) Compared to PTH and PTHrP for PTH Type 1 Receptor Conformations

G Hattersley, T Dean, T Gardella

 

June 21-24 2014
The Endocrine Society Annual Meeting - Abstract

A Transdermal Patch Delivering the PTHrP1-34 Analog, Abaloparatide (BA058), Dose-Dependently Increases Spine and Hip BMD Compared to Placebo

J Yates, P Miller, M Bolognese, G Woodson, I Valter, M Clarkin, G Hattersley, K Hansen, M Karsdal, C Christiansen

 

June 21-24 2014
The Endocrine Society Annual Meeting - Abstract

The PTHrP1-34 Analog, Abaloparatide (BA058), Induces Consistent, Marked and Rapid Increases in Hip and Spine BMD with Compared to Placebo and Teriparatide

J Yates, P Miller, M Bolognese, G Woodson, I Valter, M Clarkin, G Hattersley, M Karsdal, C Christiansen

 

May 17-20 2014
European Calcified Tissue Society -

Comparison of Osteosarcoma Incidence between Abaloparatide (BA058) and PTH(1-34) in Long Term Rat Studies

G Hattersley, B Attalla, A Varela, S Smith

 

May 17-20 2014
European Calcified Tissue Society - Abstract

Abaloparatide (BA058), a Novel Human PTHrP Analog, Restores Bone Mass and Strength in the Aged Osteopenic Ovariectomized Cynomolgus Monkey

G Hattersley, N Doyle, A Varela, R Guldberg, S Smith

 

May 17-20 2014
European Calcified Tissue Society - Poster

Abaloparatide (BA058), a Novel Human PTHrP Analog, Restores Bone Mass and Strength in the Aged Osteopenic Ovariectomized Cynomolgus Monkey

G Hattersley, N Doyle, A Varela, R Guldberg, S Smith

 

May 17-20 2014
European Calcified Tissue Society -

A Transdermal Patch Delivering the PTHrP1-34 Analog, Abaloparatide (BA058), Dose-Dependently Increases Spine and Hip Bone Mass Density Compared to Placebo

J Yates, P Alexanderson, A Krogsaa, B Nedergaard, M Clarkin, G Hattersley, K Hansen, M Karsdal, C Christiansen

 

May 17-20 2014
European Calcified Tissue Society

Consistent, Marked and Rapid Increases in Hip and Spine Bone Mass Density with the PTHrP1-34 Analog, Abaloparatide (BA058), Compared to Placebo and Teriparatide

J Yates, P Alexanderson, A Krogsaa, B Nedergaard, M Clarkin, G Hattersley, M Karsdal, C Christiansen

 

October 24-25 2013
Peptide Therapeutics Symposium - Oral Presentation

The Development of BA058, A Novel Peptide, For the Treatment of Osteoporosis.

G Hattersley

 

October 4-7 2013
American Society of Bone Mineral Research - Poster Presentation

Long Term effect of BA058, a Novel Human PTHrP Analog, Restores Bone Mass in the Aged Osteopenic Ovariectomized Cynomolgus Monkey.

N Doyle, A Varela, S Smith, G Hattersley

 

October 4-7 2013
American Society of Bone Mineral Research - Oral and Poster Presentation

BA058, a Novel Human PTHrP Analog: Reverses Ovariectomy-Induced Bone Loss and Strength at the Lumbar Spine in Aged Cynomolgus Monkeys.

N Doyle, A Varela, S Smith, R Guldberg, G Hattersley

 

October 4-7 2013
American Society of Bone Mineral Research - Poster Presentation

Safety and Tolerability of BA058 Transdermal, a Novel Analog of hPTHrP Delivered via a Microneedle Patch: Results of a Phase 2 Clinical Trial.

L Brenner, K Hansen, M Clarkin, K Heraldsen, B Juel Riis, M Bolognese, P Miller  

 

July 21-24 2013
Controlled Release Society - Poster Presentation

Development and Phase 1 Clinical Results for BA058-coated Microneedles for the Treatment of Osteoporosis.

K Hansen, D Dohmeier, T Fenn, J Moseman, D Wirtanen, J Christensen, S Schaefer, G Hattersley

 

June 22-27 2013
American Peptide Symposium - Oral Presentation

Development and Clinical Evaluation of BA058-sMTS, a Microneedle Drug Product Targeting Osteoporosis.

K Hansen, K Brown, D Wirtanen, T Fenn, J Moseman, Y Zhangm, D Dohmeier, G Hattersley

 

June 15-18 2013
The Endocrine Society Annual Meeting - Oral and Poster Presentation

BA058, a Novel Human PTHrP Analog, Restores Bone Density and Increases Bone Strength at the Spine and Femur in Osteopenic Rats.

G Hattersley, E Lesage, A Varela, S Smith

 

May 28 - June 1 2013
International Bone Mineral Society - Poster Presentation

BA058, A Human PTHrP Analog: Effects on Bone Density and Strength in the Osteopenic Rat Model.

A Varela, E Lesage, SY Smith, G Hattersley

 

May 28 - June 1 2013
International Bone Mineral Society - Oral and Poster Presentation

BA058, a Human PTHrP Analog, restores Bone Mass in the Osteopenic Monkey.

N Doyle, A Varela, SY Smith, G Hattersley

 

May 18-21 2013
European Calcified Tissue Society - Oral Presentation

Bone Anabolic Efficacy and Safety of BA058, A Novel Analog of hPTHrP: 12 Month Extension Data from a Phase 2 Clinical Trial in Postmenopausal Women with Osteoporosis.

G Hattersley, J Bilezikian, J Guerriero, P Kumar, J Zanchetta, CR Lyttle, LSL O'Dea

 

May 18-21 2013
European Calcified Tissue Society - Oral and Poster Presentation

Transdermal Delivery of BA058, a Novel Analog of hPTHrP (1-34), with a Short Wear Time Patch in Preclinical and Clinical Studies.

G Hattersley, K Hansen, A Determan, K McKay, J Guerriera, D McCarthy, LSL O'Dea, CR Lyttle

 

February 26-28 2013
AsiaTides - Oral Presentation

Development of a Novel Analog of Human PTHrP to Treat Osteoporosis.

G Hattersley

 

October 12-15 2012
ASBMR - Oral

Transdermal Delivery of BA058, A Novel Analog of hPTHrP, with a Short Wear Time Microneedle Skin Patch in Post-Menopausal Women

G Hattersley, K Hansen, A Determan, K Brown, K Mckay, J Guerriero, D McCarthy, C R Lyttle, L St L O'Dea

 

October 12-15 2012
ASBMR - Poster

Rapid Transdermal Delivery of BA058 by sMTS Microneedle Arrays; Pharmacokinetics in Rats and Monkeys, and Reversal of Bone Loss in Osteopenic Rats

G Hattersley, A Determan, K Hansen, C R Lyttle

 

October 12-15 2012
ASBMR - Poster

BA058, a Novel Human PTHrP Analog, Restores Bone Mass in the Aged Osteopenic Ovariectomized Cynomolgus Monkey

N Doyle, A Varela, S Y Smith, G Hattersley

 

October 12-15 2012
ASBMR - Poster

BA058, a Novel Human PTHrP Analog, Restores Bone Density at the Spine and Femur in Osteopenic Sprague-Dawley Rats within 13 Weeks

N Doyle, A Varela, S Y Smith, G Hattersley

 

June 23-26 2012
ENDO 2012 - Oral

Bone Anabolic Efficacy and Safety of BA058, A Novel Analog of hPTHrP: Results from a Phase 2 Clinical Trial in Postmenopausal Women with Osteoporosis

G Hattersley, J Bilezikian, J Guerriero, P Kumar, J Zanchetta, C R Lyttle, L St L O'Dea

 

June 23-26 2012
ENDO 2012 - Oral

BA058, a Novel hPTHrP Analog, Reverses Bone Loss and Improves Bone Strength in Ovariectomized Rats

G Hattersley, J Downall, M Shomali, K Gallacher and C R Lyttle.

 

June 23-26 2012
ENDO 2012 - Poster

A Selective Androgen Receptor Modulator (RAD140) Induces Inflammation In Rat Right Heart Ventricle – Evidence For An Androgen Specific, Species Specific Mechanism

C Miller, M Shomali, C R Lyttle, and G Hattersley

 

May 13-15 2012
Microneedles 2012 - Poster

Development and Clinical/Preclinical Utilization of a BA058-sMTS Microneedle Drug Product targeting Osteoporosis

K Hansen, A Determan, K Brown, D Wirtanen, T Fenn, J Moseman, Y Zhang, D Dohmeier, G Hattersley

 

April 25-28 2012
International Symposium on Osteoporosis - Poster

BA058, A Novel Analog of Human Parathyroid Hormone-related Protein: Early P1NP Elevation Precedes BMD Gains in Postmenopausal Women with Osteoporosis

G Hattersley, J Bilezikian, J Guerriero, P Kumar, J Zanchetta, C R Lyttle, L St L O'Dea

 

April 25-28 2012
International Symposium on Osteoporosis - Poster

Rapid Transdermal Delivery of BA058 by sMTS Reverses Bone Loss in Osteopenic Rats

G Hattersley, J Downall, M Shomali, K Gallacher, A Determan, K Hansen and C R Lyttle

 

March 21-24 2012
IOF-ECCE012: European Congress on Osteoporosis and Osteoarthritis - Oral

BA058, A Novel Analog of Human Parathyroid Hormone-related Protein, Exerts Significant Effects on BMD in Postmenopausal Women with Osteoporosis

G Hattersley, J Bilezikian, J Guerriero, P Kumar, J Zanchetta, C R Lyttle, L St L O'Dea

 

March 21-24 2012
IOF-ECCE012: European Congress on Osteoporosis and Osteoarthritis - Poster

The Safety of BA058 in Postmenopausal Women with Osteoporosis: Results of a Phase 2 Clinical Trial

G Hattersley, J Bilezikian, J Guerriero, P Kumar, J Zanchetta, C. Lyttle, L St L O'Dea

 

March 21-24 2012
IOF-ECCE012: European Congress on Osteoporosis and Osteoarthritis - Poster

Pharmacokinetics of Transdermal BA058 Administered by sMTS Microneedle Arrays in Rats and Monkeys

G Hattersley, A Determan, K Hansen and C R Lyttle

 

March 20-23 2012
TIDES 2012 - Invited Oral Presentation

The Challenges of Selecting and Developing a New Route of Delivery for a Novel Osteoporosis Therapeutic

G Hattersley

 

RAD1901

A Novel Selective Estrogen Receptor Modulator (SERM), Demonstrates Evidence of Efficacy on Postmenopausal Hot Flashes in an Early Phase Human Study.

LStL O'Dea, D McCarthy, J Guerriero, C Miller, G Hattersley, C R Lyttle

 

RAD140

A Novel Non-steroidal SARM with Anabolic Activity in Rats and Non-Human Primates

G Hattersley, M Shomali, K Gallacher, C R Lyttle, C Miller

 

RAD-1901

A Novel SERM, has Efficacy in an Animal Model of Vasomotor Symptoms

G Hattersley, G Paquin, S Ho, I Merchenthaler, A Ogasawara, M Nakagawa, H Ogura and C Lyttle

 

BA058

A Novel Analog of Human Parathyroid Hormone-Related Peptide (PTHrP), Induced Evidence of Bone Formation without Evidence of Bone Resportion over 7-Days of Exposure.

L St L O'Dea, C R Lyttle, C Rosen