Using the company’s biology, chemistry, and commercial development expertise, Radius is focusing on the discovery and development of novel anabolic drugs for metabolic bone diseases and on new drugs for other unmet needs in women’s health.

Core Capabilities

Radius has extensive expertise in bone biology and pharmacology as well as capabilities for identifying and characterizing new drug candidates for the treatment of osteoporosis, symptoms of menopause, and reproductive disorders. Radius has expertise in the chemistry of estrogen and other steroid-receptor ligands and capabilities for broad-scale design, synthesis, and screening for anabolic bone and muscle properties, as well as for other diseases regulated by nuclear hormone receptors. Radius also holds intellectual property related to nuclear hormone receptors.

Biology and Pharmacology

  Biological assays that allow profiling of activity of drug

   candidates against osteoblasts for their ability to affect

   apoptosis, differentiation, and maturation

  Proprietary understanding of the cellular circuitry controlling

   bone formation and inflammatory diseases

  Broad capabilities in animal models of bone disease, frailty,

   reproduction, and reproductive disorders associated with

   inflammation

Chemistry

  Medicinal chemistry capabilities in bone and related metabolic

   targets

  Proprietary understanding of the chemistry around estrogens

   and androgens

Development

  Extensive research and clinical experience in developing the

   leading classes of osteoporosis drugs, including bazedoxifene,

   Fosamax®, and Forteo®

Commercialization

  Experience launching and marketing breakthrough products

   including Neupogen® and Primaxin®

Research Focus:

     Goals

        Novel, more efficacious and safer approaches to building

         bone

        Improved convenience and compliance over conventional

         drugs

     Target Areas

        Osteoporosis

        Symptoms of menopause

        Inflammatory diseases associated with reproductive

         disorders

        Frailty associated with aging